American universities are purported to excel at technology transfer. This assumption, however, masks important features of American innovation. Attempts to emulate the US example must recognize the heterogeneity of its industries and institutions of higher education. Stanford University and the biomedical cluster in Boston, Massachusetts, illustrate the diversities that characterize this dynamic system.

In lieu of an abstract, here is a brief excerpt of the content:76 AN UNNOTICED ERROR IN HUME'S TREATISE "...the conformity between love and hatred in the agreeableness of their sensation makes them always be excited by the same objects..." Treatise, Book II, Part II, Sec. X. This passage from Hume's A Treatise of Human Nature is taken from the first edition of 1739. It can also be found in the Everyman Edition, the editions of Selby-Bigge Mossner, and Green and (...) Grosse, without editorial comment of any kind. Yet it contains a glaring and obvious error. The most superficial reading of Book II will convince one that it is love and pride that conform in the agreeableness of their sensation they are both indirect passions that aire pleasant in feeling. On the other hand, humility and hatred share in being disagree able or unpleasant impressions. This might have been a printer's error, or Hume's own mistake, and the reason for it is not hard to find. This part of Book II was called "Of love and hatred" ; the expression "love and hatred" recurs several times throughout the whole. In ei»ther the writing of the manuscript or the type setting of the text, a habit was established. Habit, which Hume himself used to explain so much else, must here be cited as the explanation of this slip. What is more interesting is the reason why such an obvious error has gone so long unnoticed. Here an ambiguity in Hume's use of the word "object" should be noticed. It is sometimes used simply as a synonym for "thing" and this is the usage in "excited by the same objects". Hume is merely saying that love and pride have the same sorts of cause. When this cause is found in oneself it leads to pride and when in another it leads to love. This of course is connected with the fact that both these passions are aggreeable or pleasant in sensation. 77 "Object" also has a special technical use in Book II when it refers to the person towards whom the passion is directed, as in "the object of the passion". Now love and hatred do have a similar sort of object, i.e. another person, whereas the object of pride and humility is, according to Hume, always oneself. In this usage, the object of a passion is carefully distinguished by Hume from its cause. It is possible that a careless and superficial reading of this passage might lead one to think that Hume meant to say that love and hatred agree in having the same sort of object, i.e. another person. Such inattention is to be deplored, but after all, until very recently, such inattention was typical of the attitude of philosophers towards Book II 2 as a whole. D. W. D. Owen University of Stirling 1.See for instance the previous paragraph; "I have suppos'd all along, that the passions of love and pride, and those of humility and hatred are similar in their sensations, and that the two former are always agreeable, and the two latter painful." 2.Thanks are due to Mr. Roland Hall for checking the first edition on my behalf.... (shrink)

Todd Moody’s Zombie Earth thought experiment is an attempt to show that ‘conscious inessentialism’ is false or in need of qualification. We defend conscious inessentialism against his criticisms, and argue that zombie thought experiments highlight the need to explain why consciousness evolved and what function(s) it serves. This is the hardest problem in consciousness studies.

Somites are transient structures which represent the most overt segmental feature of the vertebrate embryo. The strict temporal regulation of somitogenesis is of critical developmental importance since many segmental structures adopt a periodicity based on that of the somites. Until recently, the mechanisms underlying the periodicity of somitogenesis were largely unknown. Based on the oscillations of c-hairy1 and lunatic fringe RNA, we now have evidence for an intrinsic segmentation clock in presomitic cells. Translation of this temporal periodicity into a spatial (...) periodicity, through somite formation, requires Notch signaling. While the Hox genes are certainly involved, it remains unknown how the metameric vertebrate axis becomes regionalized along the antero–posterior (AP) dimension into the occipital, cervical, thoracic, lumbar, and sacral domains. We discuss the implications of cell division as a clock mechanism underlying the regionalization of somites and their derivatives along the AP axis. Possible links between the segmentation clock and axial regionalization are also discussed. BioEssays 22:72–83, 2000. ©2000 John Wiley & Sons, Inc. (shrink)

Listening comprehension input is necessary for language learning and acculturation. One approach to developing listening comprehension skills is through exposure to massive amounts of naturally occurring spoken language input. But exposure to this input is not enough; learners also need to make the comprehension corpus meaningful to their learning experience.

Simple epithelial keratins K8 and K18 are components of the intracellular cytoskeleton in the cells of the single‐layered sheet tissues inside the body. As members of the intermediate filament family of proteins, their function has been a matter for debate since they were first discovered. Whilst there is an indisputable case for a structural cell‐reinforcing function for keratins in the mutilayered squamous epithelia of external barrier tissues, some very different stress‐protective features now seem to be emerging for the simple epithelial (...) keratins. Even the emerging evidence of pathological mutations in K8/K18 looks very different from mutations in stratified epithelial keratins. K8/K18‐like keratins were probably the first to evolve and, whilst stratified epithelial (keratinocyte) keratins have diversified into a large group of keratins highly specialised for providing mechanical stability, the simple epithelial keratins have retained early features that may protect the internal epithelia from a broader range of stresses, including osmotic stress and chemical toxicity. BioEssays 25:748–758, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

Decision-making depends on bringing evidence together with values: decision theory for example employs probabilities and utilities; health economic decisions employ measures such as quality of life. The hypothesis guiding this chapter is that bringing evidence together with values in clinical decision-making requires an exercise of phronesis. Our aim however is not to justify our guiding hypothesis. It is rather to outline an account of phronesis that is in principle fit for the purposes of clinical decision-making if our guiding hypothesis is (...) correct. The chapter has three sections. Section 1 describes the growing gap between evidence and values in clinical decision-making: the missing link, we suggest, required to bridge this gap, is an appropriate account of phronesis. Section 2 provides an initial characterisation of the required account of phronesis via Michael Polanyi’s twin stipulation on the nature of tacit knowledge. Section 3 then fills out the required account using John McDowell’s characterisation of phronesis as a situation specific but at the same time conceptually structured form of practical discernment. A McDowellian account of phronesis, we argue, in satisfying Polanyi’s twin stipulation, provides an in-principle bridge between evidence and values. We conclude with a note on some of the further requirements if the gap is to be bridged not only in principle but in practice too. (shrink)

The assessment of decision-making capacity in patients with brain injuries presents a range of clinical and legal challenges. Existing guidance on the conduct of such assessments is often generic; guidance specific to patients with brain injury is sparse and coarse-grained. We report on an interview-based study of decision-making capacity in patients suffering from acquired brain injury and organic personality disorder. We identify challenges associated with the assessment of DMC in this patient population, review three bodies of relevant research from cognitive (...) neuropsychology and neurophysiology, and draw on phenomenological analysis to identify three distinct abilities that play a role in decision-making, but which can be compromised in patients with organic personality disorder. We address the challenge of translating clinical findings into legally attestable results. (shrink)

Consciousness and evolution are complex phenomena. It is sometimes thought that if adaptation explanations for some varieties of consciousness, say, conscious visual perception, can be had, then we may be reassured that at least those kinds of consciousness are not epiphenomena. But what if other varieties of consciousness, for example, dreams, are not adaptations? We sort out the connections among evolution, adaptation, and epiphenomenalism in order to show that the consequences for the nature and causal efficacy of consciousness are not (...) as dire as has sometimes been supposed. (shrink)

This chapter introduces the edited volume, The Oxford Handbook of Philosophy and Psychiatry. Published in 2013, the centenary of Karl Jaspers' General Psychopathology, the chapter draws lessons from the last hundred years for the coming century. No predictions are made. Instead, five 'conditions for flourishing' are set out: 1) Particular Problems - the importance of focussing on well-defined particular problems rather than general theory building, 2) Product- orientation - remaining always responsibly product oriented in the specific sense that both sides (...) put in the work necessary to 'go deep' with each other's fields, 3) Partnership - working in partnerships of one kind or another, 4) Process - constant reflection on process based on peer review but leaving scope for the occasional rogue voice to cut innovatively against the grain, and 5) Q - a condition of a different kind, Q is an empirically derived measure of the balance between in-group cohesion and out-group openness required to support creativity. Illustrations are given of how these five conditions for flourishing have underpinned the rapid expansion of philosophy and psychiatry in the closing decades of the twentieth century, and, correspondingly, are also reflected in the Handbook as a whole. Overviews and commentaries on individual contributions to the Handbook are given in extended editorial introductions to each of its eight sections. (shrink)

Hume: General Philosophy makes available the most significant essays published on the work of David Hume. It brings together an extensive array of often difficult to obtain essays in a convenient and accessible format for researchers, teachers and student alike. Featuring a full-length introduction form the editor, it is an indispensable international reference work.

This section concerns the question of how best to understand the scientific status of mental health care in general and psychiatry in particular. On the assumption that psychiatry is based, in part at least, on natural science, what is the nature or the general shape of that science? Some of the chapters aim at shedding light on component parts of a scientific world view: causation, explanation, natural kinds, models of medicine, etc. Others concern potentially fruitful scientific approaches to mental health (...) care, drawing on brain imaging results, phenomenology, enactivism and what can be learnt from debate of the status of psychoanalysis. One overall lesson is that twenty-first-century psychiatry needs twenty-first-century philosophy of science. (shrink)

In face of the multiple controversies surrounding the DSM process in general and the development of DSM-5 in particular, we have organized a discussion around what we consider six essential questions in further work on the DSM. The six questions involve: 1) the nature of a mental disorder; 2) the definition of mental disorder; 3) the issue of whether, in the current state of psychiatric science, DSM-5 should assume a cautious, conservative posture or an assertive, transformative posture; 4) the role (...) of pragmatic considerations in the construction of DSM-5; 5) the issue of utility of the DSM – whether DSM-III and IV have been designed more for clinicians or researchers, and how this conflict should be dealt with in the new manual; and 6) the possibility and advisability, given all the problems with DSM-III and IV, of designing a different diagnostic system. Part 1 of this article took up the first two questions. Part 2 took up the second two questions. Part 3 now deals with Questions 5 & 6. Question 5 confronts the issue of utility, whether the manual design of DSM-III and IV favors clinicians or researchers, and what that means for DSM-5. Our final question, Question 6, takes up a concluding issue, whether the acknowledged problems with the earlier DSMs warrants a significant overhaul of DSM-5 and future manuals. As in Parts 1 & 2 of this article, the general introduction, as well as the introductions and conclusions for the specific questions, are written by James Phillips, and the responses to commentaries are written by Allen Frances. (shrink)

Recently some philosophers interested in consciousness have begun to turn their attention to the question of what evolutionary advantages, if any, being conscious might confer on an organism. The issue has been pressed in recent dicussions involving David Chalmers, Todd Moody, Owen Flanagan and Thomas Polger, Daniel Dennett, and others. The purpose of this essay is to consider some of the problems that face anyone who wants to give an evolutionary explanation of consciousness. We begin by framing the problem (...) in the context of some current debates. Then we. (shrink)

The integration of artificial intelligence (AI), particularly large language models (LLMs) like OpenAI’s ChatGPT, into clinical research could significantly enhance the informed consent process. This paper critically examines the ethical implications of employing LLMs to facilitate consent in clinical research. LLMs could offer considerable benefits, such as improving participant understanding and engagement, broadening participants’ access to the relevant information for informed consent and increasing the efficiency of consent procedures. However, these theoretical advantages are accompanied by ethical risks, including the potential (...) for misinformation, coercion and challenges in accountability. Given the complex nature of consent in clinical research, which involves both written documentation (in the form of participant information sheets and informed consent forms) and in-person conversations with a researcher, the use of LLMs raises significant concerns about the adequacy of existing regulatory frameworks. Institutional Review Boards (IRBs) will need to consider substantial reforms to accommodate the integration of LLM-based consent processes. We explore five potential models for LLM implementation, ranging from supplementary roles to complete replacements of current consent processes, and offer recommendations for researchers and IRBs to navigate the ethical landscape. Thus, we aim to provide practical recommendations to facilitate the ethical introduction of LLM-based consent in research settings by considering factors such as participant understanding, information accuracy, human oversight and types of LLM applications in clinical research consent. (shrink)

Consciousness and evolution are complex phenomena. It is sometimes thought that if adaptation explanations for some varieties of consciousness, say, conscious visual perception, can be had, then we may be reassured that at least those kinds of consciousness are not epiphenomena. But what if other varieties of consciousness, for example, dreams, are not adaptations? We sort out the connections among evolution, adaptation, and epiphenomenalism in order to show that the consequences for the nature and causal efficacy of consciousness are not (...) as dire as has sometimes been supposed. (shrink)

This special issue of Foundations of Physics collects together articles representing some recent new perspectives on the hole argument in the history and philosophy of physics. Our task here is to introduce those new perspectives.

This collection offers cutting-edge chapters on themes related to the philosophical work of Owen Flanagan. Flanagan is an influential philosopher in the late 20th and early 21st Century, whose wide-ranging work spans philosophy of mind (especially consciousness, identity, and the self), ethics and moral psychology, comparative philosophy, and philosophical study of psychopathology (especially disorders of self, dreams, and addiction). Flanagan is the author of numerous scholarly and popular articles, and of 10 books. The chapters present proposals for productive interdisciplinary (...) research exploring the mind, ethics, personhood, consciousness, religious cognition, mental disorders, addiction, the narrative self, virtue, the social sciences, forgiveness, or comparative philosophy. (shrink)

The 1990’s, we’ve been told, were the decade of the brain. But without anyone announcing or declaring, much less deciding that it should be so, the 90’s were also a breakthrough decade for the study of consciousness. (Of course we think the two are related, but that is another matter altogether.) William G. Lycan leads the charge with his 1987 book Consciousness (MIT Press), and he has weighed-in again with Consciousness and Experience (1996, MIT Press). Together these two books put (...) forth Lycan’s formidable view of consciousness, extending the theory of mind that he calls ‘homuncular functionalism.’ Roughly, Lycan’s view is that conscious beings are hierarchically composed intentional systems, whose representational powers are to be understood in terms of their biological function. In this review we will call the view ‘teleological functionalism’ or ‘teleofunctionalism’ – the homuncular part, for which Lycan and Daniel Dennett argued convincingly, is now so widely accepted that it fails to distinguish Lycan’s view from other versions of functionalism. This, by itself, is a testament to the importance of Lycan’s work. (shrink)